Synthesis, Chemical Characterization and Biological Screening for Cytotoxicity and Antitumor Activity of Organotin (IV) Derivatives of 3,4-Methylenedioxy 6-nitrophenylpropenoic Acid

Molecules

Muhammad Sheeraz Ahmad²  Mukhtiar Hussain¹  Muhammad Hanif¹  Saqib Ali¹ 

[1] Department of Chemistry, Quaid-i-Azam University, Islamabad-45320, Pakistan;Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University Islamabad Pakistan; E-mail:

关键词: Antitumor;    cytotoxicity;    mass spectrometry;    multinuclear NMR;    organotin.;   

DOI  :  10.3390/12102348

来源: mdpi

【 摘 要 】

A series of mono-, di- and triorganotin compounds with general formulae [RSnL₂Cl], R = Bu (compound 3), [R₂SnL₂], where R = Me, Et, Bu, Oct (compounds 1, 2, 4 and 6) and [R₃SnL], where R = Bu, Cy and Ph (compounds 5, 7 and 8) and where L = 3,4-methylenedioxy-6-nitrophenylpropenoic acid have been prepared and characterized by elemental analysis, multinuclear (¹H-, ¹³C- and ¹¹⁹Sn-) NMR and mass spectrometry. The ligand and its respective organotin complexes were screened for cytotoxicity using the brine shrimp lethality assay and for antitumor activity using the crown gall tumor inhibition (potato disc) assay. The bioassay results support the conclusion that the biological activities of these synthetic compounds are in the following order: [RSnL₂Cl] < [R₂SnL₂] < [R₃SnL].

【 授权许可】

Unknown   
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