Sensitive Detection of Haloperidol and Hydroxyzine at Multi-Walled Carbon Nanotubes-Modified Glassy Carbon Electrodes

Sensors

Fei Huang¹  Youyuan Peng¹  Guiying Jin¹  Song Zhang¹ 

[1] id="af1-sensors-08-01879">Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, P.R. Chi

关键词: Haloperidol;    Hydroxyzine;    Multi-walled carbon nanotubes;    Detection;    Excellent characteristics;    Characterization;   

DOI  :  10.3390/s8031879

来源: mdpi

【 摘 要 】

Haloperidol (i.e. HPD) and hydroxyzine (i.e. HXY), two effective and important tranquilizers with low redox activity, were found to generate an irreversible anodic peak at about +0.86 V (vs. SCE) or two anodic peaks at about +0.83 and +0.91 V in 0.05 M NaH₂PO₄-Na₂HPO₄ (pH=7.0) buffer solution with a multi-walled carbon nanotubes-modified glassy carbon electrode (i.e. MWNTs/GC), respectively. Their sensitive and quantitative measurement based on the first two anodic peaks was established under the optimum conditions. The anodic peak current was linear to HPD and HXY concentration from 1×10^-7 to 2.5 ×10^-5 M and 5×10^-8 to 2.5 ×10^-5 M, the detection limits obtained were 8×10^-9 and 5×10^-9 M, separately. The modified electrode exhibited some excellent characteristics including easy regeneration, high stability, good reproducibility and selectivity. The method proposed was successfully applied to the detection of HPD and HXY in drug tablets and proved to be reliable compared with ultraviolet spectrophotometry. The modified electrode was characterized by electrochemical methods.

【 授权许可】

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