Synthesis of Polynucleotide Analogs Containing a Polyvinyl Alcohol Backbone

Molecules

Qiang Yu¹ 

[1] id="af1-molecules-13-00701">Department of Chemistry, Norwegian University of Science and Technology-NTNU, N-7491 Trondheim, Norw

关键词: Polynucleotide;    Nucleoside;    Polymer;    PVA;   

DOI  :  10.3390/molecules13030701

来源: mdpi

【 摘 要 】

Water soluble homo-base polynucleotide analogues were synthesized in which polyvinyl alcohol and partially phosphonated polyvinyl alcohol constituted the backbones, onto which were grafted uracil or adenine via 1,3-dioxane spacers formed by acetal formation with the 1,3-diol moieties in PVA. The resulting adenine-PVA polynucleotide analogs exhibited hyperchromic effects, which was not the case for the corresponding uracil compounds. Mixtures of the adenine- and aracil PVA-phosphate polynucleotide analogs in solutions exhibited characteristic S-shaped UV-absorbance vs temperature and melting curves with melting points at approximately 40 ^oC.

【 授权许可】

Unknown   
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