A systemic antiviral resistance‐inducing protein isolated from Clerodendrum inerme Gaertn. is a polynucleotide:adenosine glycosidase (ribosome‐inactivating protein)

FEBS Letters

Bolognesi, Andrea¹  Olivieri, Fabiola¹  Srivastava, Shalini²  Valbonesi, Paola¹  Ghosal-Chowdhury, Papiya²  Barbieri, Luigi¹  Prasad, Vivek²  Stirpe, Fiorenzo¹ 

[1] Dipartimento di Patologia Sperimentale dell'Università di Bologna, Via S. Giacomo 14, I-40126 Bologna, Italy;Unit of Applied Phytovirology, Department of Botany, University of Lucknow, Lucknow 226 007, India

关键词: Ribosome-inactivating protein;    Polynucleotide;    adenosine glycosidase;    Antiviral protein;    RIP;    ribosome-inactivating protein;   

DOI  :  10.1016/0014-5793(96)01089-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Two systemic antiviral resistance-inducing proteins, CIP-29 and CIP-34, isolated from Clerodendrum inerme Gaertn. leaves, were tested for ribosome-inactivating properties. It was found that CIP-29 has the characteristics of a polynucleotide: adenosine glycosidase (ribosome-inactivating protein), in that it inhibits protein synthesis both in cell-free systems and, at higher concentrations, in cells, and releases adenine from ribosomes, RNA, poly(A) and DNA. As compared with other known RIPs, CIP-29 deadenylates DNA at a high rate, and induces systemic antiviral resistance in susceptible plants.

【 授权许可】

Unknown