Diastereoselective Synthesis of Cyclopentanediols by InCl3/Al Mediated Intramolecular Pinacol Coupling Reaction in Aqueous Media

Molecules

Yunhua Chen²  Jieping Wan¹  Chunyan Wang¹ 

[1]Department of Chemistry, Zhejiang University, Hangzhou, 310027, P.R. China

[2]Zhejiang Hisun Pharm. Co. Ltd. Taizhou, 318000, P.R. China

关键词: Intramolecular;    Pinacol coupling;    Indium;    Aluminium;    Aqueous media;   

DOI  :  10.3390/molecules13102652

来源: mdpi

【 摘 要 】

A “green” and practical intramolecular pinacol coupling reaction promoted by InCl₃/Al catalysts in aqueous media has been developed. Under mild conditions, a novel class of polysubstituted cyclopentane-1,2-diols have been obtained with excellent diastereoselectivity.

【 授权许可】

CC BY   
© 2008 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.