Microwave Accelerated Aza-Claisen Rearrangement

Molecules

Eva Gajdošíková²  Miroslava Martinková²  Jozef Gonda¹ 

[1] Institute of Chemical Sciences, Department of Organic Chemistry, P. J. Šafárik University, Moyzesova 11, SK-040 01 Košice, Slovak Republic; E-mails

关键词: Overman rearrangement;    Imidate;    Microwave irradiation;   

DOI  :  10.3390/molecules131102837

来源: mdpi

【 摘 要 】

A study of microwave-induced and standard thermal Overman rearrangement of selected allylic trichloroacetimidates 1a-1f, 6-8 to the corresponding acetamides 2a-2f, 9- 11 is reported. The microwave-assisted rearrangement of trifluoroacetimidate 13 is also described. Using this methodology, an efficient access to versatile allylic trihaloacetamides building synthons was established.

【 授权许可】

CC BY   
© 2008 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.