International Journal of Environmental Research and Public Health | |
Potassium Dichromate Induced Cytotoxicity, Genotoxicity and Oxidative Stress in Human Liver Carcinoma (HepG2) Cells | |
Anita K. Patlolla1  Constance Barnes2  Diahanna Hackett2  | |
[1] Molecular Toxicology Research Laboratory, NIH-Center for Environmental Health, CSET, Jackson State University, Jackson, MS, USA; E-mail | |
关键词: HepG2 cells; cytotoxicity; DNA damage; lipid peroxidation; malondialdehyde; potassium dichromate; | |
DOI : 10.3390/ijerph6020643 | |
来源: mdpi | |
【 摘 要 】
Chromium is a widespread industrial waste. The soluble hexavalent chromium Cr (VI) is an environmental contaminant widely recognized to act as a carcinogen, mutagen and teratogen towards humans and animals. The fate of chromium in the environment is dependent on its oxidation state. Hexavalent chromium primarily enters the cells and undergoes metabolic reduction to trivalent chromium, resulting in the formation of reactive oxygen species together with oxidative tissue damage and a cascade of cellular events. However, the results from
【 授权许可】
CC BY
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190057596ZK.pdf | 286KB | download |