Antimicrobial Activity of Some Thiourea Derivatives and Their Nickel and Copper Complexes

Molecules

Hakan Arslan⁴  Nizami Duran³  Gulay Borekci²  Cemal Koray Ozer¹ 

[1] Department of Chemistry, Faculty of Pharmacy, Mersin University, Mersin, TR 33169, Turkey;;Health School, Mersin University, Mersin, TR 33169, Turkey; E-mail:;Department of Microbiology, Faculty of Medicine, Mustafa Kemal University, Hatay, TR 31040, Turkey; E-mail:;Department of Natural Sciences, Fayetteville State University, Fayetteville, NC 28301, USA; E-mail:

关键词: Thiourea derivatives;    Complexes;    Antibacterial activity;    Antifungal activity;    In vitro studies;    Lipophilicity;   

DOI  :  10.3390/molecules14010519

来源: mdpi

【 摘 要 】

Five thiourea derivative ligands and their Ni²⁺ and Cu²⁺ complexes have been synthesized. The compounds were screened for their in vitro anti-bacterial activity using Gram-positive bacteria (two different standard strains of Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Streptococcus pyogenes, Bacillus cereus) and Gram-negative bacteria (Esherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, Proteus vulgaris, Enterobacter aerogenes) and in vitro anti-yeast activity (Candida albicans, Candida krusei, Candida glabrata, Candida tropicalis, Candida parapsilosis). The minimum inhibitory concentration was determined for all ligands and their complexes. In vitro anti-yeast activity of both ligands and their metal complexes is greater than their in vitro anti-bacterial activity. The effect of the structure of the investigated compounds on the antimicrobial activity is discussed.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.