Comparision of the Cytotoxic Effects of Birch Bark Extract, Betulin and Betulinic Acid Towards Human Gastric Carcinoma and Pancreatic Carcinoma Drug-sensitive and Drug-Resistant Cell Lines

Molecules

Marcin Drag¹  Pawel Surowiak³  Malgorzata Drag-Zalesinska³  Manfred Dietel²  Hermann Lage² 

[1] Division of Medicinal Chemistry and Microbiology, Faculty of Chemistry, Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland; E-mail:;Charité Campus Mitte, Institute of Pathology, Chariteplatz. 1 20/21, D-10117 Berlin, Germany; E-mails:;Department of Histology and Embryology, University School of Medicine, ul. Chalubinskiego 6a, 50-356 Wroclaw, Poland; E-mails:

关键词: Betulin;    Betulinic acid;    Birch;    Gastric carcinoma;    Pancreatic carcinoma;   

DOI  :  10.3390/molecules14041639

来源: mdpi

【 摘 要 】

Betulin and betulinic acid are naturally occurring pentacyclic triterpenes showing cytotoxicity towards a number of cancer cell lines. These compounds can be found in the bark of the many plants. In this report we have compared the cytotoxic activity of crude birch bark extract and purified betulin and betulinic acid towards human gastric carcinoma (EPG85-257) and human pancreatic carcinoma (EPP85-181) drug-sensitive and drug-resistant (daunorubicin and mitoxantrone) cell lines. Our results show significant differences in sensitivity between cell lines depending on the compound used, and suggest that both betulin and betulinic acid can be considered as a promising leads in the treatment of cancer.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.