Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, Applications and Trends

Molecules

Brenno A. D. Neto¹ 

[1] ¹Laboratory of Medicinal and Technological Chemistry, University of Brasilia (IQ-UnB), Brasilia, DF, Brazil ²Universidade Federal do Pampa, Unipampa, Bagé, RS, Brazil

关键词: DNA;    RNA;    photointercalators;    fluorescence;    rational design;    therapy;    cancer;   

DOI  :  10.3390/molecules14051725

来源: mdpi

【 摘 要 】

In the present overview, we describe the bases of intercalation of small molecules (cationic and polar neutral compounds) in DNA. We briefly describe the importance of DNA structure and principles of intercalation. Selected syntheses, possibilities and applications are shown to exemplify the importance, drawbacks and challenges in this pertinent, new, and exciting research area. Additionally, some clinical applications (molecular processes, cancer therapy and others) and trends are described.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.