Pentacyclic Triterpene Distribution in Various Plants – Rich Sources for a New Group of Multi-Potent Plant Extracts

Molecules

Sebastian Jäger²  Holger Trojan²  Thomas Kopp²  Melanie N. Laszczyk¹ 

[1] Betulin-Institute, Blumenstrasse 24, D-64297 Darmstadt, Germany; E-Mail:;Carl Gustav Carus-Institute, Am Eichhof 30, D-75223 Niefern-Öschelbronn, Germany

关键词: lupane;    oleanane;    ursane;    triterpene dry extract;    active plant extracts;    triterpene distribution;   

DOI  :  10.3390/molecules14062016

来源: mdpi

【 摘 要 】

Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark. In particular the lupane-, oleanane-, and ursane triterpenes display various pharmacological effects while being devoid of prominent toxicity. Therefore, these triterpenes are promising leading compounds for the development of new multi-targeting bioactive agents. Screening of 39 plant materials identified triterpene rich (> 0.1% dry matter) plant parts. Plant materials with high triterpene concentrations were then used to obtain dry extracts by accelerated solvent extraction resulting in a triterpene content of 50 ‑ 90%. Depending on the plant material, betulin (birch bark), betulinic acid (plane bark), oleanolic acid (olive leaves, olive pomace, mistletoe sprouts, clove flowers), ursolic acid (apple pomace) or an equal mixture of the three triterpene acids (rosemary leaves) are the main components of these dry extracts. They are quantitatively characterised plant extracts supplying a high concentration of actives and therefore can be used for development of phytopharmaceutical formulations.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.