Anti-Inflammatory Triterpenoids from the Stems of Microtropis Fokienensis

Molecules

I-Hsiao Chen²  Ying-Chi Du⁷  Tsong-Long Hwang³  I-Fen Chen⁴  Yu-Hsuan Lan⁶  Hsin-Fu Yen⁵  Fang-Rong Chang¹ 

[1] Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan;Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan;Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan; E-Mail:;Department of Biomedical Engineering, College of Medicine, I Shou University, Kaohsiung 82445, Taiwan; E-Mail:;National Museum of Natural Science, Taichung 404, Taiwan; E-Mail:;School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan; E-Mail:;Department of Botanicals, Medical and Pharmaceutical Industry Technology and Development Center, New Taipei City 248, Taiwan; E-Mail:

关键词: Microtropis fokienensis;    triterpenoids;    ursane;    oleanane;    anti-inflammatory;   

DOI  :  10.3390/molecules19044608

来源: mdpi

【 摘 要 】

Three new ursane- and four new oleanane- type triterpenoids 1–7 were isolated, along with six known compounds 8–13, from the methanolic extract of Microtropis fokienensis. All structures were elucidated by mass and NMR spectroscopic methods. The isolates 4–10 and known compounds 14–17 that were previously isolated from this material were evaluated for anti-inflammatory activity based on effects against superoxide anion generation and elastase release by neutrophils in response to fMLP/CB. 11α,30-Dihydroxy-2,3-seco-olean-12-en-2,3-dioic anhydride (7) was the first triterpene anhydride from the genus of Microtropis to have the ring A expanded to a seven-membered ring; it showed significant anti-inflammatory activity against superoxide anion generation and elastase release. Unexpectedly, 30-hydroxy-2,3-seco-lup-20(29)-ene-2,3-dioic acid (17) showed the best effect against superoxide anion generation and elastase release with IC₅₀ values of 0.06 ± 0.01 and 1.03 ± 0.35 µg/mL, respectively. Compound 17 had a dioic acid function, and compound 7 had an anhydride function modification in ring A; both showed promising activity in the target assays.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.