Synthesis of 3-N-Sugar-substituted-2, 4(1H, 3H)-quinazolinediones as Anti-Angiogenesis Agents

Molecules

Conghai Huang¹  Xiangbao Meng¹  Jingrong Cui¹ 

[1] State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China; E-mails

关键词: quinazolinediones;    anti-angiogenesis;    triphosgene;   

DOI  :  10.3390/molecules14072447

来源: mdpi

【 摘 要 】

A series of novel 3-N-sugar-substituted quinazolinediones were synthesized through the cyclization of the intermediate 2-aminobenzamides using triphosgene as the condensing reagent. Their anti-angiogenesis activities were investigated. The compound 3-(2'-aminoglucosyl)-2,4-(1H,3H)-quinazolinedione, (5d) showed good anti-angiogenesis activity.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.