Influence of Different Polymer Types on the Overall Release Mechanism in Hydrophilic Matrix Tablets

Molecules

Anna Körner¹  Lennart Piculell¹  Frida Iselau¹  Bengt Wittgren¹ 

[1] ¹SCA Hygiene Products, SE-405 03 Göteborg, Sweden ²Department of Physical Chemistry 1, Lund University, Box 124, SE-221 00, Lund, Sweden ³AstraZeneca R&D, SE-431 83, Mölndal, Sweden ⁴Department of Chemistry and Bioengineering, Chalmers University of Technology, SE-412 96, Gothenburg, Sweden

关键词: hydrophilic matrix tablets;    release mechanism;    intrinsic viscosity;    PEO;    HPMC;    dextran;   

DOI  :  10.3390/molecules14082699

来源: mdpi

【 摘 要 】

The effect of three different types of polymer chain structures on the polymer release from hydrophilic matrix tablets was investigated by comparing a synthetic semi-crystalline linear polymer (PEO), a branched amorphous polysaccharide (dextran) and an amorphous substituted cellulose derivative (HPMC). The polymer release rates for tablets containing mixtures of high and low molecular weight grades in different ratios were determined by using a modified USP II method and a SEC-RI chromatography system. The results showed that independent of polymer type: (i) plots of the release versus time had similar shapes, (ii) the release of long and short polymer chains was equal and no fractionation occurred during the release and (iii) the release rate could be related to the average intrinsic viscosity of the polymer mixtures. This confirms the hypothesis that the release rate can be related to a constant viscosity on the surface of the hydrophilic matrix tablet and that it is valid for all the investigated polymers.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.