Hydration Patterns in Sodium Alginate Polymeric Matrix Tablets—The Result of Drug Substance Incorporation

Materials

Przemysław Dorożyński¹  Władysław P. Węglarz²  Dorota Majda³  Ewelina Baran⁴  Piotr Kulinowski⁴  Artur Birczyński⁴  Jolanta Klaja⁵  Encarna Garcia-Montoya⁶  Ewelina Juszczyk⁷ 

[1] Department of Drug Technology and Pharmaceutical Biotechnology, Medical University of Warsaw, Banacha 1, 02-097 Warszawa, Poland;Department of Magnetic Resonance Imaging, Institute of Nuclear Physics Polish Academy of Sciences, Radzikowskiego 152, 31-342 Kraków, Poland;Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Kraków, Poland;Institute of Technology, The Pedagogical University of Kraków, Podchorążych 2, 30-084 Kraków, Poland;Oil and Gas Institute—National Research Institute, Lubicz 25 A, 31-503 Kraków, Poland;Pharmaceutical Technology and Physico-Chemical Department, Universidad de Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain;Research and Development Center, Celon Pharma S.A., Marymoncka 15, 05-152 Kazuń Nowy, Poland;

关键词: hydrophilic matrix tablets;    sustained release drug delivery;    sodium alginate;    polymer hydration;    swelling;    drug solubility;   

DOI  :  10.3390/ma14216531

来源: DOAJ

【 摘 要 】

The purpose was to show, using destructive/nondestructive methods, that the interplay between water, tablet structure, and composition determine the unique spatiotemporal hydration pattern of polymer-based matrices. The tablets containing a 1:1 w/w mixture of sodium alginate with salicylic acid (ALG/SA) or sodium salicylate (ALG/SNA) were studied using Karl Fischer titration, differential scanning calorimetry, X-ray microtomography, and magnetic resonance imaging. As the principal results, matrix specific features were detected, e.g., “locking” of the internal part of the matrix (ALG/SA); existence of lamellar region associated with detection of free/freezing water (ALG/SA); existence of water penetrating the matrix forming specific region preceding infiltration layer (ALG/SNA); switch in the onset temperature of endothermic water peak associated with an increase in the fraction of non-freezing water weight per dry matrix weight in the infiltration layer (ALG/SNA). The existence of complicated spatiotemporal hydration patterns influenced by matrix composition and molecular properties of constituents has been demonstrated.

【 授权许可】

Unknown