Cross-Cyclotrimerization with Two Nitriles as a Synthetic Pathway to Unsymmetrically 3,3’-Disubstituted bis(Tetrahydroisoquinolines)

Molecules

Aneta Kadlčíková¹ 

[1] Department of Organic and Nuclear Chemistry, and Center for Structural and Synthetic Application of Transition Metal Complexes, Faculty of Science, Charles University in Prague, Hlavova 8, 128 43 Praha 2, Czech Republic

关键词: cyclotrimerization;    cobalt;    microwave heating;    pyridines;   

DOI  :  10.3390/molecules14082918

来源: mdpi

【 摘 要 】

Microwave assisted CpCo(CO)₂ catalyzed cross-cyclotrimerizations of 1,7,9,15-hexadecatetrayne with two different nitriles to give unsymmetrically substituted bis(tetrahydroisoquinolines) was studied. The reaction proceeded with a range of alkyl and aryl nitriles with reasonable isolated yields.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.