Antimalarial Activity of Ultra-Short Peptides

Molecules

Lemuel Pérez-Picaso¹  Benjamín Velasco-Bejarano¹  A. Berenice Aguilar-Guadarrama¹  Rocío Argotte-Ramos¹ 

[1] ¹Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa, 62209 Cuernavaca, Morelos, México

关键词: tetrapeptides;    antimalarial activity;    Plasmodium berghei;    ultra-short peptides;   

DOI  :  10.3390/molecules14125103

来源: mdpi

【 摘 要 】

Ultra-short peptides 1-9 were designed and synthesized with phenylalanine, ornithine and proline amino acid residues and their effect on antimalarial activity was analyzed. On the basis of the IC₅₀ data for these compounds, the effects of nature, polarity, and amino acid sequence on Plasmodium berghei schizont cultures were analyzed too. Tetrapeptides Phe-Orn-Phe-Orn (4) and Lys-Phe-Phe-Orn (5) showed a very important activity with IC₅₀ values of 3.31 and 2.57 μM, respectively. These two tetrapeptides are candidates for subsequent in vivo assays and SARS investigations.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.