Molecules | |
Antimalarial Activity of Ultra-Short Peptides | |
Lemuel Pérez-Picaso1  Benjamín Velasco-Bejarano1  A. Berenice Aguilar-Guadarrama1  Rocío Argotte-Ramos1  | |
[1] 1Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa, 62209 Cuernavaca, Morelos, México | |
关键词: tetrapeptides; antimalarial activity; Plasmodium berghei; ultra-short peptides; | |
DOI : 10.3390/molecules14125103 | |
来源: mdpi | |
【 摘 要 】
Ultra-short peptides 1-9 were designed and synthesized with phenylalanine, ornithine and proline amino acid residues and their effect on antimalarial activity was analyzed. On the basis of the IC50 data for these compounds, the effects of nature, polarity, and amino acid sequence on Plasmodium berghei schizont cultures were analyzed too. Tetrapeptides Phe-Orn-Phe-Orn (4) and Lys-Phe-Phe-Orn (5) showed a very important activity with IC50 values of 3.31 and 2.57 μM, respectively. These two tetrapeptides are candidates for subsequent in vivo assays and SARS investigations.
【 授权许可】
CC BY
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
【 预 览 】
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RO202003190055680ZK.pdf | 145KB | download |