Activation and Evasion of Innate Antiviral Immunity by Herpes Simplex Virus

Viruses

Jesper Melchjorsen²  Sampsa Matikainen¹ 

[1] Unit of Excellence for Immunotoxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 A, 00250 Helsinki, Finland; E-Mail: [e-mail];Department of Infectious Diseases, Aarhus University Hospital, Skejby , Denmark

关键词: herpes simplex virus;    evasion;    innate;    interferon;    viral immunity;   

DOI  :  10.3390/v1030737

来源: mdpi

【 摘 要 】

Herpes simplex virus (HSV), a human pathogenic virus, has evolved several strategies to evade the production and function of interferons (IFNs) and cytokines generated by the innate immune system to restrict the virus. Equilibrium exists between the virus and the immune response, and a shift in this delicate balance either restricts the virus or enhances virus spread and tissue damage. Therefore, understanding of the cytokine response generated after HSV infection and the underlying virus-cell interactions is essential to improve our understanding of viral pathogenesis. This review summarizes the current knowledge on induction and evasion of the innate immune response by HSV.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland