3-(2-Aminophenyl)-4-methyl-1,3-thiazole-2(3H)-thione as an Ecofriendly Sulphur Transfer Agent to Prepare Alkanethiols in High Yield and High Purity

Molecules

Mohammed Amine Mehdid¹  Ayada Djafri¹  Christian Roussel¹ 

[1] ¹Laboratoire de synthèse organique appliquée, Département de Chimie, Faculté de Sciences, Université d’Oran-es-Senia, Algeria ²ISM2, Chirosciences, Université Paul Cézanne Aix-Marseille III, 13397 Marseille CEDEX 20, France

关键词: thiols;    dithiols;    sulphur transfer;    thiazoline-2-thione;   

DOI  :  10.3390/molecules14114634

来源: mdpi

【 摘 要 】

A new process is described for preparing very pure linear alkanethiols and linear α,ω-alkanedithiols using a sequential alkylation of the title compound, followed by a ring closure to quantitatively give the corresponding 3-methyl[1,3]thiazolo[3,2-a]-[3,1]benzimidazol-9-ium salt and the alkanethiol derivative under mild conditions. The alkanethiol and the heteroaromatic salt are easily separated by a simple extraction process. The intermediate thiazolium quaternary salts resulting from the first reaction step can be isolated in quantitative yields, affording an odourless protected form of the thiols.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.