Click Chemistry for the Synthesis of RGD-Containing Integrin Ligands

Molecules

Matteo Colombo¹ 

[1] ¹NiKem Research, via Zambeletti 25, 20021 Baranzate, Milan, Italy ²Consorzio Interdisciplinare di Studi Biomolecolari ed Applicazioni Industriali (CISI), Via Fantoli 16/15, 20138 Milan, Italy

关键词: click chemistry;    RGD;    pseudopeptide;    biomaterials;    integrins;   

DOI  :  10.3390/molecules15010178

来源: mdpi

【 摘 要 】

In the last few years click chemistry reactions, and in particular coppercatalyzed cycloadditions, have been used intensively for the preparation of new bioconjugate molecules and materials applicable to biomedical and pharmaceutical areas. This review will be focused on conjugates of the tripeptide Arg-Gly-Asp formed by means of click chemistry reactions. This sequence is a well known binding motif for specific transmembrane proteins and is involved in cellular adhesion to the extracellular matrix, allowing the selective recognition of the biomolecule or polymer in which it is incorporated.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.