Hepatoprotective Potential of Extracts from Seeds of Areca catechu and Nutgalls of Quercus infectoria

Molecules

Pimolpan Pithayanukul¹  Saruth Nithitanakool¹ 

[1] ¹Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand ²Department of Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10300, Thailand

关键词: anti-inflammatory;    antioxidant;    Areca catechu L.;    hepatoprotective activity;    Quercus infectoria Oliv;   

DOI  :  10.3390/molecules14124987

来源: mdpi

【 摘 要 】

Aqueous extracts from seeds of Areca catechu L. (Arecaceae) (AC) and nutgalls of Quercus infectoria Oliv. (Fagaceae) (QI) were investigated for their hepatoprotective potential by studying their antioxidant capacity using four different methods, by determining their in vitro anti−inflammatory activity against 5-lipoxygenase, and by evaluating their hepatoprotective potential against liver injury induced by carbon tetrachloride (CCl₄) in rats. AC and QI extracts exhibited potent antioxidant and anti-inflammatory activities. Treatment of rats with AC and QI extracts reversed oxidative damage in hepatic tissues induced by CCl₄. It is suggested that extracts rich in either condensed or hydrolysable tannins and known for their potent antioxidant and anti-inflammatory activities, may potentially confer protection against oxidative stress−induced liver injury. These data should contribute to evidence-based traditional medicines for anti-inflammatory and hepatoprotective effects of both extracts.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.