Isolation, Synthesis and Structures of Ginsenoside Derivatives and Their Anti-Tumor Bioactivity

Molecules

Mei Han¹  Jin-Gang Hou¹  Cheng-Ming Dong¹  Wei Li¹  Hao-Lun Yu¹  Yi-Nan Zheng¹ 

[1] ¹College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China

关键词: isolation;    synthesis;    ginsenoside-ORh₁;   

DOI  :  10.3390/molecules15010399

来源: mdpi

【 摘 要 】

Protopanaxatriol saponins obtained with AB-8 macroporous resin mainly consisted of ginsenosides Rg₁ and Re. A novel mono-ester of ginsenoside-Rh₁ (ginsenoside-ORh₁) was synthesized through further enzymatic hydrolysis and octanoyl chloride modifications. A 53% yield was obtained by a facile synthetic method. The structures were identified on the basis of 1D-NMR and 2D-NMR, as well as ESI-TOF-MS mass spectroscopic analyses. The isolated and synthetic compounds were applied in an anti-tumor bioassay, in which ginsenoside ORh₁ showed moderate effects on Murine H22 Hepatoma Cells.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.