Synthesis of 1-(4-Trifluoromethoxyphenyl)-2,5-dimethyl-3-(2-R-thiazol-4-yl)-1H-pyrroles via Chain Heterocyclization

Molecules

Mykhaylo V. Vovk¹  Oleksandr M. Pinchuk¹  Andrij O. Tolmachov¹ 

[1] ¹Institute of Organic Chemistry, NAS of Ukraine, Murmanska 5, 02094 Kyiv, Ukraine ²National Taras Shevchenko University, Volodymyrs`ka 62, 01033 Kyiv, Ukraine ³Oak Ridge National Laboratory, Oak Ridge, TN 37831-6242, USA

关键词: pyrrole;    fluorinated heterocycles;    Paal-Knorr reaction;    trifluoromethoxy group;    chain heterocyclization;   

DOI  :  10.3390/molecules15020997

来源: mdpi

【 摘 要 】

The title compounds, (4-trifluoromethoxyphenyl)-2,5-dimethyl-3-(2-R-thiazol-4-yl)-1H-pyrroles, were prepared in four steps starting from commercially available 4-trifluoromethoxyaniline. The pyrrole (second ring) was added in one step using the Paal-Knorr method. The thiazole (third ring) was added in three steps using chloroacylation with chloroacetonitrile followed by heterocyclization with thioamides/thioureas.

【 授权许可】

CC BY   
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