The Suzuki Reaction Applied to the Synthesis of Novel Pyrrolyl and Thiophenyl Indazoles

Molecules

Antonella Migliorini¹  Chiara Oliviero¹  Tecla Gasperi² 

[1] Department of Chemistry, “Sapienza” University of Rome, P.le A. Moro 5, I-00185 Roma, Italy;Department of Mechanical and Industrial Engineering and CISDiC, University of Studies “Roma Tre”, via della Vasca Navale 79, I-00146 Roma, Italy;

关键词: indazoles;    pyrrole;    thiophene;    Suzuki cross-coupling;    heterobiaryl compounds;   

DOI  :  10.3390/molecules17044508

来源: mdpi

【 摘 要 】

The paper describes the Suzuki cross-coupling of a variety of N and C-3 substituted 5-bromoindazoles with N-Boc-2-pyrrole and 2-thiopheneboronic acids. The reactions, performed in the presence of K₂CO₃, dimethoxyethane and Pd(dppf)Cl₂ as catalyst, gave the corresponding adducts in good yields. The methodology allows the facile production of indazole-based heteroaryl compounds, a unique architectural motif that is ubiquitous in biologically active molecules.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.