Application of Nanodiamonds in Biomolecular Mass Spectrometry

Materials

Xianglei Kong¹ 

[1] Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14850, USA

关键词: nanodiamonds;    mass spectrometry;    matrix assisted laser desorption/ionization;    solid phase extraction;    peptide;    protein;    DNA oligonucleotide;    body fluid;    non-covalent interaction;    organic functionalization;   

DOI  :  10.3390/ma3031845

来源: mdpi

【 摘 要 】

The combination of nanodiamond (ND) with biomolecular mass spectrometry (MS) makes rapid, sensitive detection of biopolymers from complex biosamples feasible. Due to its chemical inertness, optical transparency and biocompatibility, the advantage of NDs in MS study is unique. Furthermore, functionalization on the surfaces of NDs expands their application in the fields of proteomics and genomics for specific requirements greatly. This review presents methods of MS analysis based on solid phase extraction and elution on NDs and different application examples including peptide, protein, DNA, glycan and others. Owing to the quick development of nanotechnology, surface chemistry, new MS methods and the intense interest in proteomics and genomics, a huge increase of their applications in biomolecular MS analysis in the near future can be predicted.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland.