A Pilot Study of Nuclear Instability in Archived Renal and Upper Urinary Tract Tumours with Putative Ochratoxin Aetiology

Toxins

Peter G. Mantle⁵  Cyrille Amerasinghe²  Amy L. Brown⁷  Diana Herman³  Thomas Horn¹  Thoger Krogh⁶  Edward W. Odell⁷  Tomas Rosenbaum⁴ 

[1] Pathology Department, Herlev Hospital, University of Copenhagen, DK-2730 Herlev, Denmark;Department of Histopathology, Ealing Hospital, Southall, Middlesex, UB1 3HW, UK;Pathology Department, County Hospital Timisoara, Romania;Department of Urology, Ealing Hospital, Southall, Middlesex. UB1 3HW, UK;Centre for Environmental Policy, Imperial College London, London SW7 2AZ, UK;Department of Rheumatology, Aarhus University Hospital, 8000 Aarhus. Denmark;Department of Oral Pathology, Kings College London, London, UK

关键词: DNA ploidy;    Balkan endemic nephropathy;    renal cell carcinoma;    ochratoxin A;    porcine nephropathy;    metastasis;    nuclear instability;    transitional cell carcinoma;    aneuploidisation;   

DOI  :  10.3390/toxins2030326

来源: mdpi

【 摘 要 】

DNA ploidy measurement has been applied uniquely to wax-embedded tissue of primary renal cell and metastatic tumours of a key experimental researcher on porcine ochratoxicosis, a control, and four transitional cell carcinomas from cases of Balkan endemic nephropathy. Primary renal tumour was diploid, and hyperdiploid metastasis was within the lower ploidy range for typical renal cell carcinoma. Three Balkan primary tumours showed extensive aneuploidy indicating marked nuclear instability, similar to model rat renal carcinoma caused by ochratoxin A. In contrast, much less nuclear instability in the putative occupational ochratoxicosis case fitted poorly with the ochratoxin A model.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland