Influence of Magnolol on the Secretion of α-Toxin by Staphylococcus aureus

Molecules

Hua Xiang¹  Jia-Zhang Qiu¹  Da-Cheng Wang¹  You-Shuai Jiang¹  Li-Jie Xia¹ 

[1] ¹Institute of Zoonoses, College of Animal Sciences and Veterinary Medicine, Jilin University, Changchun, Jilin 130062, China

关键词: magnolol;    Staphylococcus aureus;    α-toxin;   

DOI  :  10.3390/molecules15031679

来源: mdpi

【 摘 要 】

In this study we investigated the antimicrobial activity of magnolol on Staphylococcus aureus. The minimal inhibitory concentrations of magnolol against 31 S. aureus strains ranged from 4–32 μg/mL. In addition, hemolysin assays, Western blotting, and real-time RT-PCR were performed to investigate the effect of magnolol on α-toxin secretion by both methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA). The results indicated that sub-inhibitory concentrations of magnolol dose-dependently inhibited the transcription of hla (the gene encoding α-toxin) in S. aureus, resulting in a reduction of α-toxin secretion and, thus, hemolytic activities.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.