The Heck Reaction Applied to 1,3- and 1,2-Unsaturated Derivatives, a Way towards Molecular Complexity

Molecules

Annamaria Deagostino¹  Cristina Prandi¹  Silvia Tabasso¹ 

[1] Dipartimento di Chimica Generale e Chimica Organica, Università di Torino, Via Pietro Giuria, 7, I 10125, Torino, Italy

关键词: Mizoroki–Heck reaction;    palladium;    1;    2-dienes;    1;    3-dienes;   

DOI  :  10.3390/molecules15042667

来源: mdpi

【 摘 要 】

This review is an overview of the last ten years’ use of the Mizoroki–Heck coupling applied to 1,2- and 1,3-dienes. Since both these systems form π-allyl palladium intermediates in Pd(0) coupling, they show particular chemical behavior. Many examples of 1,2-dienes Heck reactions are presented. 1,2-Dienes are important substrates because of their high reactivity that makes them useful building blocks for the synthesis of biologically relevant structures.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.