Access to Original Vinylic Chlorides in the Quinazoline Series via a Monoelectronic Transfer Reaction Approach

Molecules

Martine Maillard-Boyer¹  Caroline Castera-Ducros¹  Pierre Verhaeghe¹  France Sifredi¹  Pascal Rathelot¹ 

[1] Laboratoire de Pharmacochimie Radicalaire, Faculté de Pharmacie, Universités d’Aix-Marseille I, II et III - UMR CNRS 6264, Laboratoire Chimie Provence, 27 Boulevard Jean Moulin, 13385 Marseille cedex 05, France

关键词: S_RN1;    E_RC1;    quinazoline ring;    vinylic chlorides;   

DOI  :  10.3390/molecules15042719

来源: mdpi

【 摘 要 】

A series of new quinazoline derivatives bearing a vinylic chloride group on the 2-position was prepared by using a consecutive S_RN1 / E_RC1 radical strategy.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.