Microtubule-Stabilizing Drugs from Marine Sponges: Focus on Peloruside A and Zampanolide

Marine Drugs

John H. Miller¹  A. Jonathan Singh² 

[1] School of Biological Sciences and Centre for Biodiscovery, Victoria University of Wellington, PO Box 600, Wellington, New Zealand;School of Chemical and Physical Sciences and Centre for Biodiscovery, Victoria University of Wellington, PO Box 600, Wellington, New Zealand; E-Mails:

关键词: mycalamide;    pateamine;    peloruside;    zampanolide;    microtubule stabilization;   

DOI  :  10.3390/md8041059

来源: mdpi

【 摘 要 】

Marine sponges are an excellent source of bioactive secondary metabolites with potential therapeutic value in the treatment of diseases. One group of compounds of particular interest is the microtubule-stabilizing agents, the most well-known compound of this group being paclitaxel (Taxol^®), an anti-cancer compound isolated from the bark and leaves of the Pacific yew tree. This review focuses on two of the more recent additions to this important class of drugs, peloruside A and zampanolide, both isolated from marine sponges. Peloruside A was isolated from Mycale hentscheli collected in New Zealand coastal waters, and it already shows promising anti-cancer activity. Two other potent bioactive compounds with different modes of action but isolated from the same sponge, mycalamide A and pateamine, will also be discussed. The fourth compound, zampanolide, most recently isolated from the Tongan sponge Cacospongia mycofijiensis, has only recently been added to the microtubule-stabilizing group of compounds, and further work is in progress to determine its activity profile relative to peloruside A and other drugs of this class.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland