International Journal of Environmental Research and Public Health | |
Assessment of Benzo(a)pyrene-equivalent Carcinogenicity and Mutagenicity of Residential Indoor |
|
Kyung Hwa Jung2  Beizhan Yan1  Steven N. Chillrud1  Frederica P. Perera3  Robin Whyatt3  David Camann4  Patrick L. Kinney3  | |
[1] Lamont-Doherty Earth Observatory, Columbia University, 61 Rt, 9W Palisades, NY 10964, USA; E-Mails:;Division of Pulmonary, Allergy and Critical Care of Medicine, College of Physicians and Surgeons, Columbia University, PH8E, 630 W. 168 St. New York, NY 10032, USA; E-Mail:;Mailman School of Public Health, Department of Environmental Health Sciences, Columbia University, 60 Haven Ave., B-1 New York, NY 10032, USA; E-Mails:;Southwest Research Institute, 6220 Culebra Road, San Antonio, TX 78228, USA; E-Mail: | |
关键词: risk assessment; PAH; BaP-equivalents; TEF; MEF; heating season; indoor; outdoor; and children; | |
DOI : 10.3390/ijerph7051889 | |
来源: mdpi | |
【 摘 要 】
The application of benzo(a)pyrene (BaP)-toxic equivalent factor to polycyclic aromatic hydrocarbons (PAH) concentrations can provide a more accurate risk assessment from environmental exposure to PAH. We hypothesized that BaP-equivalent toxicity determined following residential air monitoring among young urban children may vary by season. Residential indoor and outdoor air levels of PAH measured over two-weeks in a cohort of 5–6 year old children (n = 260) in New York City were normalized to the cancer and mutagen potency equivalent factor of BaP (BaP = 1). Data are presented as carcinogenic equivalents (BaP-TEQ) and mutagenic equivalents (BaP-MEQ) for the sum of 8 PAH (Σ8PAH; MW ≥ 228) and individual PAH and compared across heating versus nonheating seasons. Results show that heating compared to nonheating season was associated significantly with higher (BaP-TEQ)Σ8PAH and (BaP-MEQ)Σ8PAH both indoors and outdoors (p < 0.001). Outdoor (BaP-TEQ)Σ8PAH and (BaP-MEQ)Σ8PAH were significantly higher than the corresponding indoor measures during the heating season (p < 0.01). These findings suggest that at levels encountered in New York City air, especially during the heating season, residential exposure to PAH may pose an increased risk of cancer and mutation.
【 授权许可】
CC BY
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202003190053855ZK.pdf | 208KB | download |