Synthesis of N-(Methoxycarbonylthienylmethyl)thioureas and Evaluation of Their Interaction with Inducible and Neuronal Nitric Oxide Synthase

Molecules

Ghadeer A.R.Y. Suaifan¹  Claire L.M. Goodyer¹ 

[1] ¹Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman, Jordan ²Department of Pharmacy & Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK

关键词: nitric oxide synthase;    iNOS;    stimulation;    thienylmethylthioureas;   

DOI  :  10.3390/molecules15053121

来源: mdpi

【 摘 要 】

Two isomeric N-(methoxycarbonylthienylmethyl)thioureas were synthesised by a sequence of radical bromination of methylthiophenecarboxylic esters, substitution with trifluoroacetamide anion, deprotection, formation of the corresponding isothiocyanates and addition of ammonia. The interaction of these new thiophene-based thioureas with inducible and neuronal nitric oxide synthase was evaluauted. These novel thienylmethylthioureas stimulated the activity of inducible Nitric Oxide Synthase (iNOS).

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.