The Reaction of Cyanoacetylhydrazine with ω-Bromo(4-methyl)acetophenone: Synthesis of Heterocyclic Derivatives with Antitumor Activity

Molecules

Rafat M. Mohareb¹ 

[1] ¹Department of Organic Chemistry, Faculty of Pharmacy, October University for Modern Sciences and Arts, October City, A.R., Egypt ²Department of Chemistry, Faculty of Science, Cairo University, Giza, A.R., Egypt ³National Organization for Drug Control & Research (NODCAR), P.O. 29, Cairo, Egypt

关键词: hydrazide-hydrazone;    1;    3;    4-triazine;    pyridine;    pyridazine;    antitumor;   

DOI  :  10.3390/molecules15053602

来源: mdpi

【 摘 要 】

New approaches for the synthesis of hydrazide-hydrazone derivatives were demonstrated as well as some heterocyclizations of such derivatives to afford 1,3,4-triazine, pyridine and 1,3,4-oxadiazine derivatives. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Most of the synthesized compounds showed high inhibitory effects.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.