Novel Synthesis of Hydrazide-Hydrazone Derivatives and Their Utilization in the Synthesis of Coumarin, Pyridine, Thiazole and Thiophene Derivatives with Antitumor Activity

Molecules

Rafat M. Mohareb¹  Daisy H. Fleita¹ 

[1] ¹Department of Organic Chemistry, Faculty of Pharmacy, October University for Modern Sciences and Arts, October City, A.R., Egypt ²Department of Chemistry, Faculty of Science, Cairo University, Giza, A.R., Egypt ³Department of Chemistry, Faculty of Science, American University in Cairo, 5th Settlement, A.R., Egypt

关键词: hydrazide-hydrazone;    3-acetylpyridine;    thiophene;    coumarin;    antitumor activity;   

DOI  :  10.3390/molecules16010016

来源: mdpi

【 摘 要 】

The reaction of cyanoacetyl hydrazine (1) with 3-acetylpyridine (2) gave the hydrazide-hydrazone derivative 3. The latter compound undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) was performed. Most of the synthesized compounds showed high inhibitory effects.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.