Synthesis and Effect on Human HepG2 Cells of 1,2-bis- (2-Methylallyl)disulfane

Molecules

Chunxiao Ji¹  Fenglian Ren¹  Jun Dai¹ 

[1] ¹College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China ²Research Institute for Molecular Pharmacology and Therapeutics, Central South University, Changsha, Hunan 410083, China

关键词: 1;    2-bis(2-methylallyl)disulfane;    identification;    apoptosis;   

DOI  :  10.3390/molecules15053634

来源: mdpi

【 摘 要 】

1,2-bis(2-methylallyl)disulfane was synthesized from sodium sulfide and 3-chloro-2-methylpropylene. The structure of the target product was confirmed by GC-MS, 1H-NMR and elemental analysis. Cell viability assay, flow-cytometric analysis and protein expression results showed that 1,2-bis(2-methylallyl)disulfane could significantly inhibit the proliferation, and induce the apoptosis of human HepG2 cells.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.