Platelet Proteome and Tumor Dormancy: Can Platelets Content Serve as Predictive Biomarkers for Exit of Tumors from Dormancy?

Cancers

Nava Almog¹ 

关键词: tumor dormancy;    angiogenesis;    platelets;    early tumor detection;   

DOI  :  10.3390/cancers2020842

来源: mdpi

【 摘 要 】

Although tumor dormancy is highly prevalent, the underling mechanisms are still mostly unknown. It is unclear which lesions will progress and become a disseminated cancer, and which will remain dormant and asymptomatic. Yet, an improved ability to predict progression would open the possibility of timely treatment and improvement in outcomes. We have recently described the ability of platelets to selectively uptake angiogenesis regulators very early in tumor growth, and proposed their use as an early marker of malignancy. In this review we will summarize current knowledge about these processes and will discuss the possibility of using platelet content to predict presence of occult tumors.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland.