Building Cell Selectivity into CPP-Mediated Strategies

Pharmaceuticals

Irene Martín¹  Meritxell Teixidó¹ 

[1] Institute for Research in Biomedicine (IRB Barcelona), Barcelona Science Park, Baldiri Reixac 10, Barcelona, Spain; E-Mail:

关键词: cell-penetrating peptides (CPPs);    targeted drug delivery;    homing peptides;    selective targeting;    peptide transduction domains (PTDs);   

DOI  :  10.3390/ph3051456

来源: mdpi

【 摘 要 】

There is a pressing need for more effective and selective therapies for cancer and other diseases. Consequently, much effort is being devoted to the development of alternative experimental approaches based on selective systems, which are designed to be specifically directed against target cells. In addition, a large number of highly potent therapeutic molecules are being discovered. However, they do not reach clinical trials because of their low delivery, poor specificity or their incapacity to bypass the plasma membrane. Cell-penetrating peptides (CPPs) are an open door for cell-impermeable compounds to reach intracellular targets. Putting all these together, research is sailing in the direction of the design of systems with the capacity to transport new drugs into a target cell. Some CPPs show cell type specificity while others require modifications or form part of more sophisticated drug delivery systems. In this review article we summarize several strategies for directed drug delivery involving CPPs that have been reported in the literature.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland.