Wnt and Related Signaling Pathways in Melanomagenesis

Cancers

Jesse J. Keller¹  Randall T. Moon¹ 

[1] University of Washington School of Medicine, Seattle, WA 98195, USA; E-Mails:

关键词: Wnts;    morphogens;    melanoma;    signal transduction;   

DOI  :  10.3390/cancers2021000

来源: mdpi

【 摘 要 】

Given the pivotal roles of morphogen pathways including Wnt, Notch, Hedgehog, and BMP pathways in the development of the neural crest lineage, it is not surprising that these signaling networks have also been implicated in the biology of malignant melanoma. Understanding the mechanisms by which these pathways can alter cell fate and other biological properties in tumor cells will be essential for determining whether the therapeutic targeting of these pathways has a potential role in melanoma treatment. This review highlights some of the recent findings with regards to how morphogen signaling may regulate melanoma cell biology.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland.