Biomarkers for Basal-like Breast Cancer

Cancers

Jennifer R. Choo¹ 

[1] Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada; E-Mail

关键词: breast cancer;    basal-like;    biomarkers;    intrinsic subtype;    immunohistochemistry;    triple-negative;    basaloid;    expression profile;   

DOI  :  10.3390/cancers2021040

来源: mdpi

【 摘 要 】

Initially recognized through microarray-based gene expression profiling, basal-like breast cancer, for which we lack effective targeted therapies, is an aggressive form of carcinoma with a predilection for younger women. With some success, immunohistochemical studies have attempted to reproduce the expression profile classification of breast cancer through identification of subtype-specific biomarkers. This review aims to present an in depth summary and analysis of the current status of basal-like breast cancer biomarker research. While a number of biomarkers show promise for future clinical application, the next logical step is a comprehensive investigation of all biomarkers against a gene expression profile gold standard for breast cancer subtype assignment.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland.