Cannabinoids and Viral Infections

Pharmaceuticals

关键词: pathogens;    virus infection;    immunomodulation;    inflammation;   

DOI  :  10.3390/ph3061873

来源: mdpi

【 摘 要 】

Exogenous cannabinoids or receptor antagonists may influence many cellular and systemic host responses. The anti-inflammatory activity of cannabinoids may compromise host inflammatory responses to acute viral infections, but may be beneficial in persistent infections. In neurons, where innate antiviral/pro-resolution responses include the activation of NOS-1, inhibition of Ca²⁺ activity by cannabinoids, increased viral replication and disease. This review examines the effect(s) of cannabinoids and their antagonists in viral infections.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland.