Effect of Moisture on Powder Flow Properties of Theophylline

Pharmaceutics

Niklas Sandler¹  Katharina Reiche²  Jyrki Heinämäki² 

[1] Pharmaceutical Sciences, Department of Biosciences, Åbo Akademi University, Turku, Finland;Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, Finland

关键词: powder flow;    relative humidity;    equilibrium moisture content;    solid-state properties;    theophylline;   

DOI  :  10.3390/pharmaceutics2030275

来源: mdpi

【 摘 要 】

Powder flow is influenced by environmental factors, such as moisture and static electricity, as well as powder related factors, such as morphology, size, size distribution, density, and surface area. Pharmaceutical solids may be exposed to water during storage in an atmosphere containing water vapor, or in a dosage form consisting of materials (e.g., excipients) that contain water and are capable of transferring in to other ingredients. The effect of moisture on powder flowability depends on the amount of water and its distribution. The aim of this work was to examine the effect of humidity on the flow properties of theophylline using information derived from solid-state analysis of the systems investigated.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland.