Chitosan Modification and Pharmaceutical/Biomedical Applications

Marine Drugs

Jiali Zhang²  Wenshui Xia²  Ping Liu¹  Qinyuan Cheng²  Talba Tahirou²  Wenxiu Gu³ 

[1] Jiangsu Animal Husbandry and Veterinary College, Taizhou 225300, Jiangsu, China;State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu, China;School of Chemical Engineering, Jiangnan University, Wuxi 214122, China

关键词: chitosan derivatives;    hypocholesterolemic;    immunoenhancing;    homeostasis;    D-Glucosaminic Acid;   

DOI  :  10.3390/md8071962

来源: mdpi

【 摘 要 】

Chitosan has received much attention as a functional biopolymer for diverse applications, especially in pharmaceutics and medicine. Our recent efforts focused on the chemical and biological modification of chitosan in order to increase its solubility in aqueous solutions and absorbability in the in vivo system, thus for a better use of chitosan. This review summarizes chitosan modification and its pharmaceutical/biomedical applications based on our achievements as well as the domestic and overseas developments: (1) enzymatic preparation of low molecular weight chitosans/chitooligosaccharides with their hypocholesterolemic and immuno-modulating effects; (2) the effects of chitin, chitosan and their derivatives on blood hemostasis; and (3) synthesis of a non-toxic ion ligand—D-Glucosaminic acid from Oxidation of D-Glucosamine for cancer and diabetes therapy.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland