Plant Natural Compounds with Antibacterial Activity towards Common Pathogens of Pond-Cultured Channel Catfish (Ictalurus punctatus)

Toxins

关键词: antibacterial;    channel catfish;    chelerythrine;    columnaris;    ellagic acid;    enteric septicemia of catfish;    β-glycyrrhetinic acid;    sorgoleone;    therapeutant;    wogonin;   

DOI  :  10.3390/toxins2071676

来源: mdpi

【 摘 要 】

The bacteria Edwardsiella ictaluri and Flavobacterium columnare cause enteric septicemia and columnaris disease, respectively, in channel catfish (Ictalurus punctatus). Natural therapeutants may provide an alternative to current management approaches used by producers. In this study, a rapid bioassay identified plant compounds as potential therapeutants. Chelerythrine chloride and ellagic acid were the most toxic toward E. ictaluri, with 24-h IC50 of 7.3 mg/L and 15.1 mg/L, respectively, and MIC of 2.1 mg/L and 6.5 mg/L, respectively. Chelerythrine chloride, ellagic acid, β-glycyrrhetinic acid, sorgoleone, and wogonin were the most toxic towards two genomovars of F. columnare, and wogonin had the strongest antibacterial activity (MIC = 0.3 mg/L).

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland