Carijoside A, a Bioactive Sterol Glycoside from an Octocoral Carijoa sp. (Clavulariidae)

Marine Drugs

Chih-Yang Liu²  Tsong-Long Hwang⁴  Mei-Ru Lin¹  Yung-Husan Chen¹  Yu-Chia Chang²  Lee-Shing Fang⁵  Wei-Hsien Wang¹  Yang-Chang Wu³ 

[1] National Museum of Marine Biology and Aquarium, Checheng, Pingtung 944, Taiwan; E-Mails:;Department of Life Science and Graduate Institute of Biotechnology, Graduate Institute of Marine Biotechnology, National Dong Hwa University, Checheng, Pingtung 944, Taiwan; E-Mails:;Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan;Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan; E-Mail:;Department of Sport, Health, and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan; E-Mail:

关键词: Carijoa;    carijoside;    glycoside;    superoxide anion;    elastase;    cytotoxicity;   

DOI  :  10.3390/md8072014

来源: mdpi

【 摘 要 】

A new bioactive sterol glycoside, 3β-O-(3′,4′-di-O-acetyl-β-d-arabinopyranosyl) -25ξ-cholestane-3β,5α,6β,26-tetrol-26-acetate) (carijoside A, 1), was isolated from an octocoral identified as Carijoa sp. The structure of glycoside 1 was established by spectroscopic methods and by comparison with spectral data for the other known glycosides. Carijoside A (1) displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils and this compound exhibited moderate cytotoxicity toward DLD-1, P388D1, HL-60, and CCRF-CEM tumor cells.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland