Endocrine Disruptors and Obesity: An Examination of Selected Persistent Organic Pollutants in the NHANES 1999–2002 Data

International Journal of Environmental Research and Public Health

Mai A. Elobeid²  David W. Brock¹  David B. Allison²  Miguel A. Padilla³ 

[1] Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL 35294, USA; E-Mail:;Department of Biostatistics, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL, USA, 35294; E-Mail:;Department of Psychology, Old Dominion University, 250 Mills Godwin Building, Norfolk, VA 23529, USA; E-Mail:

关键词: Obesity;    endocrine disruptors;    waist circumference;    persistent organic pollutants;    public health;   

DOI  :  10.3390/ijerph7072988

来源: mdpi

【 摘 要 】

Recent evidence suggests that endocrine disrupting chemicals (EDCs) may cause perturbations in endogenous hormonal regulation that predispose to weight gain. Using data from NHANES (1999–2002), we investigated the association between body mass index (BMI), waist circumference (WC) and selected persistent organic pollutants (POPs) via multiple linear regressions. Consistent interaction was found between gender, ln oxychlordane and ln p,p’ DDT. Also, we found an association between WC and ln oxychlordane and ln hpcdd in subjects with detectable levels of POPs, whereas an association between WC and ln p,p’ DDT was observed in all subjects. Furthermore, ln Ocdd showed an increase with higher WC and BMI, whereas, ln trans-nonachlor decreased with higher BMI. Hence, BMI and WC are associated with POPs levels, making the chemicals plausible contributors to the obesity epidemic.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.