Synthesis and Anti-Hyperlipidemic Evaluation of N‑(Benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide Derivatives in Triton WR-1339-Induced Hyperlipidemic Rats

Molecules

Ghassan Shattat¹  Rania Al-Qirim¹  Yusuf Al-Hiari¹  Ghassan Abu Sheikha¹  Tariq Al-Qirim¹  Waseem El-Huneidi¹ 

[1] ¹Faculty of Pharmacy, Al-Zaytoonah Private University, Amman, Jordan ²Faculty of Pharmacy, University of Jordan, Amman, Jordan

关键词: Triton WR-1339-induced hyperlipidemic rats;    N-(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamides;    high-density lipoprotein-cholesterol;    triglycerides;    hypolipidemic activity;   

DOI  :  10.3390/molecules15095840

来源: mdpi

【 摘 要 】

The lipid-lowering activity of a series of novel N-(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide derivatives has been studied in Triton WR-1339-induced hyperlipidemia in rats. The test animals were divided into four groups: control, hyperlipidemic, compound + 4% DMSO [C1: N-(2-benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide (1), C2: N-(3-benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide (2), C3: N-(4-benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide (3)]-treated and bezafibrate (BF)-treated. At a dose of 15 mg/Kg body weight, compounds 2, 3 and BF significantly reduced elevated plasma triglycerodes levels after 12 h. Moreover, high density lipoprotein-cholesterol levels were significantly increased in all treated groups after 12 h compared to the hyperlipidemic control group, except for C1 which was inactive. In sum, it may be stated that the results of the present study demonstrated new properties of some N-(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide derivatives as potent lipid lowering agents and these beneficial activities may contribute to their cardioprotective and antiatherosclerotic role.

【 授权许可】

CC BY   
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