Antihyperlipidemic Properties of Novel N-(Benzoylphenyl)-5-substituted-1H-indole-2-carboxamides in Triton WR-1339-Induced Hyperlipidemic Rats

Molecules

Yusuf Al-Hiari¹  Ghassan Shattat¹  Tariq Al-Qirim¹  Waseem El-Huneidi¹  Ghassan Abu Sheikha¹ 

[1] ¹Faculty of Pharmacy, University of Jordan, Amman-11942, Jordan ²Faculty of Pharmacy, Al-Zaytoonah Private University, Amman-11733, Jordan

关键词: Triton WR-1339-induced hyperlipidemic rats;    N-(benzoylphenyl)-5-methoxy-1H-indole-2-carboxamide;    N-(Benzoylphenyl)-5-chloro-1H-indole-2-carboxamide;    hypo-lipidemic activity;   

DOI  :  10.3390/molecules16108292

来源: mdpi

【 摘 要 】

In the search for new potential antihyperlipidemic agents, the present study focuses on the synthesis of novel N-(benzoylphenyl)-5-substituted-1H-indole-2-carboxamides (compounds 8-12, 15, 16, 18) and investigating their antihyperlipidemic activity using Triton WR-1339-induced hyperlipidemic rats as an experimental model. Hyperlipidemia was developed by intraperitoneal injection of Triton WR-1339 (250 mg/kg body weight). The tested animals were divided into normal control (NCG), hyperlipidemic (HG), compound 8, 9, 15, 16, 18- and bezafibrate treated groups. At a dose of 15 mg/kg body weight, compounds 9, 16, 18 and bezafibrate (100 mg/kg) significantly (p < 0.0001) reduced elevated plasma triglycerides levels after 12 h compared to the hyperlipidemic control group. However, only the group treated with compounds 9, 16 and 18 showed an obviously significant (p < 0.001) reduction in plasma total cholesterol levels after 12 h compared to the hyperlipidemic control group. Moreover, high density lipoprotein-cholesterol levels were significantly (p < 0.0001) increased in all treated groups after 12 h compared to the hyperlipidemic control group, except for compounds 8 and 15 which revealed inactive. It is therefore reasonable to assume that compounds 9, 16 and 18 may have potential in the treatment of hyperlipidemia.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.