Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides

Molecules

J. Mikael Hillgren¹  Markus K. Dahlgren¹  Tam M. To¹ 

[1] Department of Chemistry, Umeå University, SE-90187, Umeå, Sweden

关键词: type III secretion;    Suzuki coupling;    Grignard addition;   

DOI  :  10.3390/molecules15096019

来源: mdpi

【 摘 要 】

A focused library of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones was prepared in a four-step synthesis with the aim to obtain potent inhibitors of type III secretion in Gram-negative bacteria. The compounds are potential bioisosteres of salicylidene acylhydrazides that are a known class of type III secretion inhibitors.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.