Synthesis of 2-(2-Aminopyrimidine)-2,2-difluoroethanols as Potential Bioisosters of Salicylidene Acylhydrazides

Molecules

Markus K. Dahlgren¹  Christopher T. Öberg¹  Erika A. Wallin¹  Pär G. Janson¹ 

[1] Department of Chemistry, Umeå University, SE-90187 Umeå, Sweden

关键词: scaffold hopping;    Reformatsky reaction;    salicylidene acylhydrazide;    type III secretion;   

DOI  :  10.3390/molecules15064423

来源: mdpi

【 摘 要 】

Salicylidene acylhydrazides are inhibitors of type III secretion in several Gram-negative pathogens. To further develop the salicylidene acylhydrazides, scaffold hopping was applied to replace the core fragment of the compounds. The novel 2-(2-amino-pyrimidine)-2,2-difluoroethanol scaffold was identified as a possible analog to the salicylidene acylhydrazide core structure. The synthesis of a library of 2-(2-amino-pyrimidine)-2,2-difluoro-ethanols is described in this paper.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.