Antioxidant Activity of Butyl- and Phenylstannoxanes Derivedfrom 2-, 3- and 4-Pyridinecarboxylic Acids

Molecules

Alicia Corona-Bustamante¹  Juan Manuel Viveros-Paredes¹  Angelina Flores-Parra¹  Ana Lilia Peraza-Campos¹  Francisco J. Martínez-Martínez¹  María Teresa Sumaya-Martínez¹ 

[1] ¹Facultad de Ciencias Químicas, Universidad de Colima, kilómetro 9 carretera Colima, Coquimatlán, Col. Mexico. C.P. 28400, Mexico

关键词: antioxidant activity;    pyridinecarboxylate;    organotin;    DPPH;    ferric-reducing;   

DOI  :  10.3390/molecules15085445

来源: mdpi

【 摘 要 】

In vitro antioxidant activity for 12 stannoxanes derived from Ph₃SnCl (compounds 1-3), Ph₂SnCl₂ (compounds 4-6), Bu₃SnCl (compounds 7-9), and Bu₂SnCl₂ (compounds 10-12), was assayed qualitatively by the chromatographic profile with 1,1-diphenyl-2-picrylhydrazil (DPPH) method and by two quantitative methods: the DPPH radical scavenging activity and Ferric-Reducing Antioxidant Power (FRAP) assays. The results were compared with those obtained with the starting materials 2-pyridine- carboxylic acid (I), 3-pyridinecarboxylic acid (II) and 4-pyridinecarboxylic acid (III), as well as with standard compounds, such as vitamin C and vitamin E, respectively. The in vitro antiradical activity with DPPH of diphenyltin derivative 5 showed a very similar behavior to vitamin C at a 20 µg/mL concentration, whereas according to the FRAP method, compound 8 was better. This difference is due to the mechanism of the antioxidant process. The Structure-Activity Relationships (SAR) for both methods is also reported.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.